Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 7/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774331 | 1.00 | SPHK1 (0.39) | SPHK1DRD2SLC6A2HTR2AHTR2C | |
| SCHEMBL8774422 | 0.96 | PANK3 (0.35) | SPHK1DRD2SLC6A2HTR2AHTR2C | |
| SCHEMBL8774430 | 0.96 | PANK3 (0.35) | SPHK1DRD2SLC6A2HTR2AHTR2C | |
| SCHEMBL8774803 | 0.91 | PANK3 (0.36) | DRD2 | |
| SCHEMBL8774794 | 0.91 | PANK3 (0.36) | DRD2 | |
| SCHEMBL9159238 | 0.88 | SPHK1 (0.39) | SPHK1DRD2SLC6A2HTR2AHTR2C | |
| SCHEMBL9159228 | 0.88 | SPHK1 (0.39) | SPHK1DRD2SLC6A2HTR2AHTR2C | |
| SCHEMBL8774490 | 0.88 | SPHK1 (0.54) | SPHK1HTR2ASPHK2 | |
| SCHEMBL8774483 | 0.88 | SPHK1 (0.54) | SPHK1HTR2ASPHK2 | |
| SCHEMBL9766639 | 0.86 | SPHK1 (0.39) | SPHK1DRD2SLC6A2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |