Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774477 | 1.00 | MAPT (0.40) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774257 | 0.99 | MAPT (0.38) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774245 | 0.99 | MAPT (0.38) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774504 | 0.96 | CYP2C9 (0.36) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774511 | 0.96 | CYP2C9 (0.36) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774824 | 0.91 | CYP2C9 (0.42) | MAPTCYP2C9DGAT1SOAT1CYP3A4 | |
| SCHEMBL8774814 | 0.91 | CYP2C9 (0.42) | MAPTCYP2C9DGAT1SOAT1CYP3A4 | |
| SCHEMBL8774875 | 0.89 | MAPT (0.40) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774881 | 0.89 | MAPT (0.40) | MAPTGAASPHK1CYP2C9DGAT1 | |
| SCHEMBL8774681 | 0.86 | TRPV3 (0.37) | CYP2C9DGAT1SOAT1CYP3A4ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |