Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774579 | 1.00 | EGLN1 (0.33) | EGLN1MRGPRX4PGK1RENCTSD | |
| SCHEMBL8775115 | 0.91 | RAB9A (0.35) | EGLN1MRGPRX4PGK1CYP3A4ALDH1A1 | |
| SCHEMBL8775126 | 0.91 | RAB9A (0.35) | EGLN1MRGPRX4PGK1CYP3A4ALDH1A1 | |
| SCHEMBL8774512 | 0.91 | RAB9A (0.39) | EGLN1CYP3A4NPC1LMNARAB9A | |
| SCHEMBL8774525 | 0.91 | RAB9A (0.39) | EGLN1CYP3A4NPC1LMNARAB9A | |
| SCHEMBL8774935 | 0.89 | RAB9A (0.38) | MRGPRX4CYP3A4LMNARAB9A | |
| SCHEMBL8774930 | 0.89 | RAB9A (0.38) | MRGPRX4CYP3A4LMNARAB9A | |
| SCHEMBL8775061 | 0.89 | RAB9A (0.38) | LMNARAB9A | |
| SCHEMBL8775065 | 0.89 | RAB9A (0.38) | LMNARAB9A | |
| SCHEMBL9153798 | 0.85 | EGLN1 (0.32) | EGLN1PGK1NQO1CACNA2D1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |