Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774697 | 1.00 | SOS1 (0.34) | SOS1SPHK1DRD2PANK3LSS | |
| SCHEMBL8774565 | 0.90 | SPHK1 (0.39) | SOS1SPHK1DRD2 | |
| SCHEMBL8774574 | 0.90 | SPHK1 (0.39) | SOS1SPHK1DRD2 | |
| SCHEMBL8774560 | 0.88 | SPHK1 (0.35) | SPHK1IDO1ALDH1A1MAPT | |
| SCHEMBL8774570 | 0.88 | SPHK1 (0.35) | SPHK1IDO1ALDH1A1MAPT | |
| SCHEMBL8774226 | 0.88 | SPHK1 (0.46) | SPHK1 | |
| SCHEMBL8774234 | 0.88 | SPHK1 (0.46) | SPHK1 | |
| SCHEMBL8774633 | 0.87 | SPHK1 (0.51) | SPHK1 | |
| SCHEMBL8774650 | 0.87 | SPHK1 (0.51) | SPHK1 | |
| SCHEMBL9157415 | 0.78 | SPHK1 (0.34) | SPHK1DRD2PANK3LSSCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |