Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774570 | 1.00 | SPHK1 (0.35) | SPHK1IDO1ALDH1A1MAPTMC4R | |
| SCHEMBL8775009 | 0.89 | SPHK1 (0.42) | SPHK1SPHK2 | |
| SCHEMBL8775016 | 0.89 | SPHK1 (0.42) | SPHK1SPHK2 | |
| SCHEMBL8774690 | 0.88 | SOS1 (0.34) | SPHK1IDO1ALDH1A1MAPT | |
| SCHEMBL8774697 | 0.88 | SOS1 (0.34) | SPHK1IDO1ALDH1A1MAPT | |
| SCHEMBL8774873 | 0.87 | SPHK1 (0.49) | SPHK1SPHK2 | |
| SCHEMBL8774869 | 0.87 | SPHK1 (0.49) | SPHK1SPHK2 | |
| SCHEMBL8774102 | 0.86 | PANK3 (0.38) | — | |
| SCHEMBL8774094 | 0.86 | PANK3 (0.38) | — | |
| SCHEMBL8774490 | 0.85 | SPHK1 (0.54) | SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |