Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 15/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774689 | 1.00 | OPRL1 (0.37) | OPRL1CYP2C9ALDH1A1MAPTLMNA | |
| SCHEMBL8774838 | 0.96 | OPRL1 (0.35) | OPRL1CYP2C9ALDH1A1MAPTLMNA | |
| SCHEMBL8774401 | 0.91 | GAA (0.38) | OPRL1CYP2C9MAPTLMNAMEN1 | |
| SCHEMBL8774389 | 0.91 | GAA (0.38) | OPRL1CYP2C9MAPTLMNAMEN1 | |
| SCHEMBL8775233 | 0.90 | MAPT (0.40) | OPRL1CYP2C9MAPTMEN1MAPK1 | |
| SCHEMBL8775240 | 0.90 | MAPT (0.40) | OPRL1CYP2C9MAPTMEN1MAPK1 | |
| SCHEMBL8774787 | 0.87 | GAA (0.36) | OPRL1CYP2C9MAPTLMNAMEN1 | |
| SCHEMBL8774929 | 0.87 | TRPV3 (0.36) | OPRL1ALDH1A1 | |
| SCHEMBL8774937 | 0.87 | TRPV3 (0.36) | OPRL1ALDH1A1 | |
| SCHEMBL8774738 | 0.86 | MAPT (0.38) | OPRL1CYP2C9MAPTMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |