Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774715 | 1.00 | MAPT (0.37) | MAPTGAASCN9ALMNAMAPK1 | |
| SCHEMBL8774348 | 0.97 | SCN9A (0.36) | MAPTGAASCN9ALMNAMAPK1 | |
| SCHEMBL8774344 | 0.97 | SCN9A (0.36) | MAPTGAASCN9ALMNAMAPK1 | |
| SCHEMBL8774785 | 0.93 | SCN9A (0.38) | SCN9AHTTPOLBHPGDKMT2A | |
| SCHEMBL8774777 | 0.93 | SCN9A (0.38) | SCN9AHTTPOLBHPGDKMT2A | |
| SCHEMBL8774649 | 0.90 | MAPT (0.39) | MAPTGAASCN9ALMNAMAPK1 | |
| SCHEMBL8774658 | 0.90 | MAPT (0.39) | MAPTGAASCN9ALMNAMAPK1 | |
| SCHEMBL8774310 | 0.89 | HPGD (0.35) | SCN9ALMNANPC1POLBHPGD | |
| SCHEMBL8774305 | 0.89 | HPGD (0.35) | SCN9ALMNANPC1POLBHPGD | |
| SCHEMBL8775007 | 0.87 | MAPT (0.37) | MAPTGAASCN9ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |