Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774785 | 1.00 | SCN9A (0.38) | SCN9AHPGDKMT2AMEN1RAB9A | |
| SCHEMBL8774715 | 0.93 | MAPT (0.37) | SCN9AHPGDKMT2AHTTPOLB | |
| SCHEMBL8774723 | 0.93 | MAPT (0.37) | SCN9AHPGDKMT2AHTTPOLB | |
| SCHEMBL8774348 | 0.92 | SCN9A (0.36) | SCN9AHPGDKMT2AMEN1HTT | |
| SCHEMBL8774344 | 0.92 | SCN9A (0.36) | SCN9AHPGDKMT2AMEN1HTT | |
| SCHEMBL8774305 | 0.91 | HPGD (0.35) | SCN9AHPGDKMT2AMEN1RAB9A | |
| SCHEMBL8774310 | 0.91 | HPGD (0.35) | SCN9AHPGDKMT2AMEN1RAB9A | |
| SCHEMBL8774026 | 0.89 | KMT2A (0.35) | SCN9AHPGDKMT2AMEN1RAB9A | |
| SCHEMBL8774033 | 0.89 | KMT2A (0.35) | SCN9AHPGDKMT2AMEN1RAB9A | |
| SCHEMBL8774795 | 0.86 | KMT2A (0.33) | SCN9AHPGDKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |