Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469720 | 0.90 | TDP1 (0.44) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL7298111 | 0.72 | TDP1 (0.40) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL2243721 | 0.72 | MEN1 (0.48) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL6688479 | 0.72 | MAPT (0.51) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL31180267 | 0.72 | MAPT (0.51) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL31207333 | 0.72 | MEN1 (0.48) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL1346122 | 0.71 | PARP1 (0.34) | TSHRALDH1A1 | |
| SCHEMBL4689264 | 0.70 | MAPT (0.50) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL5839690 | 0.70 | MAPT (0.43) | MAPTTDP1TSHRSMN1; SMN2GPR35 | |
| SCHEMBL9452622 | 0.69 | MAPT (0.47) | MAPTTDP1TSHRSMN1; SMN2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804415-A1 | NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996022278-A1 | NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1996-07-25 | — | — | WO | disclosed |