Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.37 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584941 | 0.74 | TDP1 (0.40) | TDP1GPR35TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL2962443 | 0.73 | MAPT (0.47) | TDP1GPR35TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL8774762 | 0.72 | MAPT (0.43) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7469720 | 0.71 | TDP1 (0.44) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8948801 | 0.71 | PARP1 (0.49) | TDP1GPR35TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL7298106 | 0.69 | TDP1 (0.41) | TDP1GPR35TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL10659420 | 0.69 | ALDH1A1 (0.42) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL2247062 | 0.68 | MAPT (0.49) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7301421 | 0.67 | TRPA1 (0.33) | TSHRALDH1A1MCL1 | |
| SCHEMBL6257481 | 0.66 | TXNRD1 (0.62) | TDP1GPR35TXNRD1TXNRD3TXNRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |