SCHEMBL8775660

SCHEMBL8775660

CC(C)(C)OC(=O)NC1CN(Cc2ccccc2)CC12CC2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
NPFFR1 Q9GZQ6 6/20 0.49
NPFFR2 Q9Y5X5 6/20 0.49
KCNA3 P22001 1/20 0.42
SCN1A P35498 1/20 0.40
SCN8A Q9UQD0 1/20 0.40
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP2D6 P10635 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA7 P43166 1/20 0.39
CA14 Q9ULX7 1/20 0.39
MCHR1 Q99705 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
GRIN2B Q13224 1/20 0.39
CTSS P25774 1/20 0.39
CTSK P43235 1/20 0.39
DRD2 P14416 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9245843 1.00 KMT2A (0.51) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL16472447 0.96 KMT2A (0.52) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL12492872 0.96 KMT2A (0.52) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL12492873 0.96 KMT2A (0.52) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL15147400 0.90 KMT2A (0.48) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL3203686 0.89 SIGMAR1 (0.44) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL6170470 0.86 KMT2A (0.48) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL6170475 0.86 KMT2A (0.48) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL6170476 0.86 KMT2A (0.48) KMT2AL3MBTL1NPFFR1NPFFR2KCNA3
SCHEMBL31598442 0.85 NPY2R (0.42) KMT2ASCN1ASCN8AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0529688-B1 Azaspiro(n,m)alkanes and diazaspiro(n,m)-alkanes DAIICHI SEIYAKU CO (JP) 1997-11-12 EP disclosed
US-5508428-A Spiro compound DAIICHI PHAMACEUTICAL CO., LTD. (JP) 1996-04-16 US disclosed
US-5286723-A Spiro compound DAIICHI SEIYAKU CO., LTD. 1994-02-15 US disclosed
EP-0357047-B1 Spiro compounds DAIICHI SEIYAKU CO (JP) 1993-11-03 EP disclosed
EP-0529688-A2 Azaspiro n,m alkanes and diazaspiro n,m -alkanes DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1993-03-03 EP disclosed
EP-0357047-A1 Spiro compounds DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1990-03-07 EP disclosed