Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775 | 1.00 | MAPT (0.42) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL13635 | 0.93 | MEN1 (0.43) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL9404 | 0.89 | MEN1 (0.43) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL9405 | 0.89 | MEN1 (0.43) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL9314 | 0.82 | MEN1 (0.48) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL14321926 | 0.82 | ALDH1A1 (0.39) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL14321924 | 0.82 | ALDH1A1 (0.39) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL13644 | 0.81 | MAPT (0.43) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL8834 | 0.81 | POLB (0.47) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL9775 | 0.81 | POLB (0.47) | MAPTMEN1KMT2AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |