Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.45 |
| ▸ | CTSD | P07339 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875669 | 0.72 | BACE1 (0.77) | BACE1CTSD | |
| SCHEMBL892490 | 0.70 | BACE1 (0.48) | BACE1CTSDAKR1B1 | |
| SCHEMBL877188 | 0.70 | AKR1B1 (0.46) | BACE1CTSDAKR1B1APP | |
| SCHEMBL876606 | 0.69 | AKR1B1 (0.43) | BACE1CTSDAKR1B1APP | |
| SCHEMBL891809 | 0.67 | BACE1 (0.39) | BACE1CTSDAKR1B1APP | |
| SCHEMBL8613061 | 0.66 | AKR1B1 (0.42) | BACE1CTSDAKR1B1APP | |
| SCHEMBL8613068 | 0.66 | AKR1B1 (0.42) | BACE1CTSDAKR1B1APP | |
| SCHEMBL8515485 | 0.63 | BACE1 (0.34) | BACE1CTSDAKR1B1 | |
| SCHEMBL877046 | 0.63 | BACE1 (0.43) | BACE1CTSDAKR1B1APP | |
| SCHEMBL8512036 | 0.63 | BACE1 (0.52) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040641-A2 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-03-29 | — | — | WO | disclosed |