Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.50 |
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348767 | 0.91 | NPC1 (0.58) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL15798268 | 0.81 | NPC1 (0.56) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL15143091 | 0.80 | NPC1 (0.43) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL1668213 | 0.80 | MAPT (0.62) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL1664550 | 0.79 | RAB9A (0.48) | NPC1RAB9APKMSMN1; SMN2KMT2A | |
| SCHEMBL29348766 | 0.78 | NPC1 (0.62) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL1779536 | 0.76 | RAB9A (0.66) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL8770348 | 0.75 | NPC1 (0.51) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL3674376 | 0.75 | TRPV1 (0.76) | NPC1RAB9APKMPOLBSMN1; SMN2 | |
| SCHEMBL8770378 | 0.75 | KCNK3 (0.58) | NPC1RAB9APKMSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |