Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8776158 | 1.00 | TP53 (0.45) | TP53MDM2HCRTR1HCRTR2KMT2A | |
| SCHEMBL30748923 | 0.82 | HCRTR2 (0.47) | TP53MDM2HCRTR1HCRTR2P2RX7 | |
| SCHEMBL30748727 | 0.82 | HCRTR2 (0.47) | TP53MDM2HCRTR1HCRTR2P2RX7 | |
| SCHEMBL23513155 | 0.76 | CYP3A4 (0.50) | TP53MDM2HCRTR1HCRTR2KMT2A | |
| SCHEMBL7407552 | 0.76 | HCRTR2 (0.50) | TP53MDM2HCRTR1HCRTR2KMT2A | |
| SCHEMBL2265479 | 0.76 | HCRTR2 (0.50) | TP53MDM2HCRTR1HCRTR2KMT2A | |
| SCHEMBL28065531 | 0.75 | KMT2A (0.51) | HCRTR1HCRTR2KMT2AP2RX7CYP3A4 | |
| SCHEMBL7020132 | 0.75 | KMT2A (0.51) | HCRTR1HCRTR2KMT2AP2RX7CYP3A4 | |
| SCHEMBL31239576 | 0.75 | P2RX7 (0.54) | HCRTR1HCRTR2KMT2AP2RX7CYP3A4 | |
| SCHEMBL8279100 | 0.75 | P2RX7 (0.54) | HCRTR1HCRTR2KMT2AP2RX7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449011-B1 | Stereoselective process for the preparation of 2-amino-ethanol derivatives having a central analgesic activity and intermediates thereof | ZAMBON SPA (IT) | 1997-10-08 | — | — | EP | disclosed |
| US-5142066-A | STEREOSELECTIVE PROCESS FOR THE PREPARATION OF 2-AMINO-ETHANOL DERIVATIVES HAVING A CENTRAL ANALGESIC ACTIVITY AND INTERMIDIATES THEREOF | ZAMBON GROUP S.P.A (IT) | 1992-08-25 | — | — | US | disclosed |
| EP-0449011-A2 | Stereoselective process for the preparation of 2-amino-ethanol derivatives having a central analgesic activity and intermediates thereof | ZAMBON GROUP S.p.A. (IT) | 1991-10-02 | — | — | EP | disclosed |