Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098732 | 0.92 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL8776887 | 0.91 | PTGS2 (0.85) | PTGS2PTGS1MEN1KMT2ACNR1 | |
| SCHEMBL8776708 | 0.84 | PTGS2 (0.63) | PTGS2PTGS1MEN1KMT2ACNR1 | |
| SCHEMBL8093078 | 0.84 | PTGS2 (0.83) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL8093929 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8776857 | 0.81 | PTGS2 (0.70) | PTGS2PTGS1CNR1 | |
| SCHEMBL8099213 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL8086783 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL8095458 | 0.81 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL8094071 | 0.80 | PTGS2 (0.80) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |