Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098107 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8776738 | 0.80 | PTGS2 (0.50) | ALOX5PTGS2PTGS1 | |
| SCHEMBL8519868 | 0.78 | TRPV1 (0.42) | PTGS2ALDH1A1LMNAPTGS1ADORA1 | |
| SCHEMBL215180 | 0.74 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL7682212 | 0.73 | HPGD (0.55) | ALOX5PIK3CDALDH1A1LMNAADORA1 | |
| SCHEMBL8100978 | 0.72 | CNR1 (0.47) | ALOX5ALDH1A1LMNAPTGS1 | |
| SCHEMBL8095222 | 0.71 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6904881 | 0.71 | PTGS2 (0.68) | ALOX5PTGS2ALDH1A1HSD11B1PTGS1 | |
| SCHEMBL8098348 | 0.71 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL7833269 | 0.70 | PTGS2 (0.64) | ALOX5PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |