SCHEMBL8777211

SCHEMBL8777211

CC(C)(C(O)C(F)(F)F)[N+](=O)[O-]

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3273563 0.74
SCHEMBL11042921 0.74 ALDH1A1 (0.45) ALDH1A1KDM4E
SCHEMBL10899437 0.72
SCHEMBL11407312 0.70
SCHEMBL38659612 0.68 ALDH1A1 (0.41) ALDH1A1KDM4E
Nitric Acid SCHEMBL8584436 0.68 ALDH1A1 (0.41) ALDH1A1KDM4E
SCHEMBL8605702 0.68
SCHEMBL10628980 0.67 ALDH1A1 (0.35) ALDH1A1KDM4E
SCHEMBL28086990 0.67 ALDH1A1 (0.40) ALDH1A1KDM4E
SCHEMBL10935741 0.67 TSHR (0.46) ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0611374-B1 17-BETA-SUBSTITUTED 4-AZA-5-ALPHA-ANDROSTAN-3-ONE DERIVATIVES PHARMACIA & UPJOHN SPA (IT) 1997-10-22 EP disclosed
US-5418238-A 17β-substituted 4-aza-5α-androstan-3-one derivatives FARMITALIA CARLO ERBA S.R.L. (IT) 1995-05-23 US disclosed
EP-0611374-A1 17-g(b)-SUBSTITUTED 4-AZA-5-g(a)-ANDROSTAN-3-ONE DERIVATIVES. ERBA FARMITALIA (IT) 1994-08-24 EP disclosed
WO-1994003476-A1 17β-SUBSTITUTED 4-AZA-5α-ANDROSTAN-3-ONE DERIVATIVES FARMITALIA CARLO ERBA S.R.L. (IT) 1994-02-17 WO disclosed