Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663848 | 0.92 | TNIK (0.47) | TNIKMAOBMAPK10MAPK8MAPK13 | |
| SCHEMBL27918370 | 0.91 | TNIK (0.46) | TNIKMAOBMAPK10MAPK8SYK | |
| SCHEMBL1663344 | 0.90 | MAOB (0.56) | TNIKMAOBMAPK10MAPK8MAPK13 | |
| SCHEMBL27936958 | 0.90 | TNIK (0.47) | TNIKMAOBMAPK10MAPK8SYK | |
| SCHEMBL1666463 | 0.90 | MAPT (0.52) | TNIKMAOBMAPK10MAPK8MAPK13 | |
| SCHEMBL8771617 | 0.90 | MGLL (0.46) | TNIKMAOBMAPK10MAPK8MAPK13 | |
| SCHEMBL1664924 | 0.90 | MAOB (0.46) | TNIKMAOBMAPK10MAPK8SYK | |
| SCHEMBL27937054 | 0.89 | TNIK (0.46) | TNIKMAOBMAPK10MAPK8SYK | |
| SCHEMBL28946999 | 0.89 | TNIK (0.47) | TNIKMAOBMAPK10MAPK8SYK | |
| SCHEMBL1665595 | 0.89 | ABL1 (0.48) | TNIKMAOBMAPK10MAPK8MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |