SCHEMBL8777761

SCHEMBL8777761

COc1cc(N)c(Cl)cc1NC(=O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.64
MEN1 O00255 2/20 0.64
SMN1; SMN2 Q16637 3/20 0.60
MAPK1 P28482 2/20 0.60
MAPT P10636 1/20 0.60
AHR P35869 1/20 0.60
KDM4E B2RXH2 4/20 0.59
ALDH1A1 P00352 2/20 0.59
NPSR1 Q6W5P4 1/20 0.58
HDAC1 Q13547 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
HSD17B10 Q99714 1/20 0.54
PDE4D Q08499 1/20 0.53
HDAC2 Q92769 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27855549 0.89 KDM4E (0.59) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL592866 0.87 MEN1 (0.74) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL29405219 0.87 MEN1 (0.74) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL4223927 0.87 KDM4E (0.75) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL5475142 0.85 MEN1 (0.66) KMT2AMEN1SMN1; SMN2MAPK1MAPT
Hydrochloric Acid SCHEMBL11120074 0.85 MEN1 (0.70) KMT2AMEN1SMN1; SMN2MAPK1MAPT
Hydrochloric Acid SCHEMBL11120075 0.85 MEN1 (0.70) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL11598085 0.85 MEN1 (0.69) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL11691486 0.84 MEN1 (0.60) KMT2AMEN1SMN1; SMN2MAPK1MAPT
SCHEMBL9760053 0.83 HDAC1 (0.60) KMT2AMEN1SMN1; SMN2MAPK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US claimed
CN-102186931-B Azo pigment, coloring composition, coloring method, and colored article DAINICHISEIKA COLOR CHEM 2013-06-12 CN disclosed
CN-102186931-A Azo pigment, coloring composition, coloring method, and colored article DAINICHISEIKA COLOR CHEM 2011-09-14 CN disclosed
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
US-5559216-A AZO COUPLING HOECHST AG (DE) 1996-09-24 US disclosed
US-5493011-A PIGMENTING HIGH MOLECULAR WEIGHT NATURAL OR SYNTHETIC ORGANIC MATERIALS HOECHST AG (DE) 1996-02-20 US disclosed
EP-0518909-B1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AG (DE) 1994-05-25 EP disclosed
EP-0585873-A1 Method of preparing disazo pigments HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-09 EP disclosed
EP-0518909-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE. HOECHST AG (DE) 1992-12-23 EP disclosed
EP-0316649-B1 WATER INSOLUBLE AZO COLOURING AGENTS, THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-22 EP disclosed
US-4225489-A Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties BAYER AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4224025-A Process for the dyeing and printing of paper materials in different hues using a single coupling component CIBA-GEIGY CORPORATION (US) 1980-09-23 US disclosed
EP-0008627-A2 Quinazoline derivatives, azo dyes derived from the quinazolines and their use as pigments BAYER AG (DE) 1980-03-19 EP disclosed
US-4187218-A Water-soluble acid azo dye MONTEDISON S.P.A. (IT) 1980-02-05 US disclosed
US-4168952-A ACETOACETIC ACID ARYLAMIDE AS COUPLER HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1979-09-25 US disclosed
US-4165967-A HYDROXY-PYRIDINE OR PYRIDONE COUPLERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1979-08-28 US disclosed
US-4162893-A Process for dyeing human hair with diazo salts HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1979-07-31 US disclosed
US-4094636-A DIAZOTIZATION HOECHST AKTIENGESELLSCHAFT (DT) 1978-06-13 US disclosed
US-4065254-A DIAZO DYES, LEATHER, COTTON, WOOL CIBA-GEIGY CORPORATION (US) 1977-12-27 US disclosed
US-4014863-A LACQUERS, PRINTING INKS, PAINTS BAYER AKTIENGESELLSCHAFT (DT) 1977-03-29 US disclosed