SCHEMBL5475142

SCHEMBL5475142

COc1cc(N)c(C)cc1NC(=O)c1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.66
KMT2A Q03164 4/20 0.66
MAPK1 P28482 3/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
MAPT P10636 2/20 0.61
AHR P35869 1/20 0.61
ALDH1A1 P00352 1/20 0.60
HDAC1 Q13547 2/20 0.58
HDAC8 Q9BY41 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
CYP1A2 P05177 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
KDM4E B2RXH2 1/20 0.56
HSD17B10 Q99714 1/20 0.56
HDAC2 Q92769 3/20 0.54
HDAC3 O15379 1/20 0.53
POLB P06746 1/20 0.53
HPGD P15428 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27626674 0.89 MEN1 (0.58) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL592866 0.89 MEN1 (0.74) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL29405219 0.89 MEN1 (0.74) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL16231124 0.88 MEN1 (0.73) MEN1KMT2AMAPK1SMN1; SMN2MAPT
Hydrochloric Acid SCHEMBL11120074 0.86 MEN1 (0.70) MEN1KMT2AMAPK1SMN1; SMN2MAPT
Hydrochloric Acid SCHEMBL11120075 0.86 MEN1 (0.70) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL11598085 0.86 MEN1 (0.69) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL8777761 0.85 KMT2A (0.64) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL825844 0.84 MEN1 (0.76) MEN1KMT2AMAPK1SMN1; SMN2MAPT
SCHEMBL9861801 0.84 MAPT (0.68) MEN1KMT2AMAPK1MAPTHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US claimed
JP-10108693-A None JP disclosed
CN-1814680-B Fluorescent colourant compositions, colouring process and coloured articles DAINICHISEIKA COLOR & CHEMICALS MANUFACTURING CO., LTD. (JP) 2011-12-21 CN disclosed
US-20070251414-A1 Red Ink Composition for Color Filter KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO 2007-11-01 US disclosed
US-20060229439-A1 Monoazo compounds and process for preparing the same KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) 2006-10-12 US disclosed
US-20060219976-A1 Fluorescent colorant compositions, coloring process and colored articles DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) 2006-10-05 US disclosed
EP-1693426-A1 RED INK COMPOSITION FOR COLOR FILTER KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) 2006-08-23 EP disclosed
EP-1688473-A2 Fluorescent colourant compositions, colouring process and coloured articles Dainichiseika Color & Chemicals Mfg. Co., Ltd. (JP) 2006-08-09 EP disclosed
CN-1814680-A Fluorescent colourant compositions, colouring process and coloured articles DAINICHISEIKA COLOR CHEM (JP) 2006-08-09 CN disclosed
EP-1650267-A1 MONOAZO COMPOUND AND METHOD FOR PRODUCING SAME Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) 2006-04-26 EP disclosed
JP-H10108693-A ASSAY OF NUCLEIC ACID OR THE LIKE AISIN SEIKI CO LTD 1998-04-28 JP disclosed
EP-0008627-B1 QUINAZOLINE DERIVATIVES, AZO DYES DERIVED FROM THE QUINAZOLINES AND THEIR USE AS PIGMENTS BAYER AG (DE) 1984-10-03 EP disclosed
US-4421601-A LACQUERS, INKS, PAINTS, TEXTILES, PAPER BAYER AKTIENGESELLSCHAFT (DE) 1983-12-20 US disclosed
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US disclosed
US-4260540-A SPIN DYEING POLYACRYLONITRILE BAYER AKTIENGESELLSCHAFT (DE) 1981-04-07 US disclosed
US-4246401-A Axomethine pigments BAYER AKTIENGESELLSCHAFT (DE) 1981-01-20 US disclosed
US-4225489-A Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties BAYER AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
EP-0008627-A2 Quinazoline derivatives, azo dyes derived from the quinazolines and their use as pigments BAYER AG (DE) 1980-03-19 EP disclosed
US-4014863-A LACQUERS, PRINTING INKS, PAINTS BAYER AKTIENGESELLSCHAFT (DT) 1977-03-29 US disclosed