Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL31122181 | 1.00 | FFAR3 (0.37) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Bicarbonate SCHEMBL30446842 | 1.00 | FFAR3 (0.37) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Bicarbonate SCHEMBL1357297 | 1.00 | FFAR3 (0.37) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Bicarbonate SCHEMBL8777797 | 1.00 | FFAR3 (0.37) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Acetic Acid SCHEMBL5145909 | 0.91 | FFAR3 (0.41) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Acetic Acid SCHEMBL1321915 | 0.91 | FFAR3 (0.41) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Acetic Acid SCHEMBL540582 | 0.91 | FFAR3 (0.41) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Acetic Acid SCHEMBL3683188 | 0.91 | FFAR3 (0.41) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Oxalic Acid SCHEMBL28437631 | 0.91 | FFAR3 (0.35) | FFAR3ALDH1A1TDP1TSHRHDAC1 | |
| Acetic Acid SCHEMBL29697739 | 0.91 | FFAR3 (0.41) | FFAR3ALDH1A1TDP1TSHRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665260-B1 | Curable resin composition | NIPPON PAINT CO LTD (JP) | 1997-12-29 | — | — | EP | claimed |
| US-5466754-A | Cyclic alkylene carbonate groups, polyol, acid catalyst | NIPPON PAINT CO., LTD. (JP) | 1995-11-14 | — | — | US | claimed |
| EP-0665260-A2 | Curable resin composition | Nippon Paint Co., Ltd. (JP) | 1995-08-02 | — | — | EP | claimed |
| EP-0057360-A2 | Cyclic carbonic acid derivatives, process for their preparation and their use as copolymerisation constituents for the preparation of polycarbonates | BAYER AG (DE) | 1982-08-11 | — | — | EP | claimed |
| EP-0665260-B1 | Curable resin composition | NIPPON PAINT CO LTD (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5466754-A | Cyclic alkylene carbonate groups, polyol, acid catalyst | NIPPON PAINT CO., LTD. (JP) | 1995-11-14 | — | — | US | disclosed |
| EP-0665260-A2 | Curable resin composition | Nippon Paint Co., Ltd. (JP) | 1995-08-02 | — | — | EP | disclosed |
| EP-0369249-B1 | Process for the preparation of cyclic carbonates | BAYER AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| EP-0057360-B1 | CYCLIC CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS COPOLYMERISATION CONSTITUENTS FOR THE PREPARATION OF POLYCARBONATES | BAYER AG (DE) | 1984-09-26 | — | — | EP | disclosed |
| EP-0057360-A2 | Cyclic carbonic acid derivatives, process for their preparation and their use as copolymerisation constituents for the preparation of polycarbonates | BAYER AG (DE) | 1982-08-11 | — | — | EP | disclosed |