Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023935 | 0.82 | KDM4E (0.51) | KDM4ESLC1A5P2RX7PDE4APDE4B | |
| SCHEMBL6827514 | 0.82 | KDM4E (0.51) | KDM4ESLC1A5P2RX7LTA4HPTGS2 | |
| SCHEMBL27290163 | 0.82 | KDM4E (0.51) | KDM4ESLC1A5P2RX7LTA4HPTGS2 | |
| SCHEMBL8287033 | 0.82 | KDM4E (0.51) | KDM4ESLC1A5P2RX7LTA4HPTGS2 | |
| Hydrochloric Acid SCHEMBL3291564 | 0.81 | KDM4E (0.50) | KDM4ESLC1A5P2RX7LTA4HPTGS2 | |
| SCHEMBL11138427 | 0.80 | KDM4E (0.66) | KDM4ESLC1A5LTA4HPTGS2LMNA | |
| SCHEMBL9359315 | 0.78 | KDM4E (0.63) | KDM4ESLC1A5LTA4HPTGS2LMNA | |
| SCHEMBL24018801 | 0.78 | SLC6A4 (0.53) | KDM4ESLC1A5P2RX7ALDH1A1 | |
| SCHEMBL5018822 | 0.78 | KDM4E (0.47) | KDM4ESLC1A5P2RX7LTA4HPTGS2 | |
| SCHEMBL4611564 | 0.77 | CXCL8 (0.56) | KDM4ESLC1A5P2RX4CYP1A2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5541218-A | Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0651743-A1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002459-A1 | INDOLINYL N-HYDROZYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-02-03 | — | — | WO | disclosed |
| EP-0030867-A1 | Process for the preparation of substituted pyridinyloxy ethers | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-06-24 | — | — | EP | disclosed |
| US-4266063-A | FROM A HALOPYRIDINE AND HYDROQUINONE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-05-05 | — | — | US | disclosed |