SCHEMBL8778070

SCHEMBL8778070

COc1cc(N=O)cc2c1OC1(C=C2)N(Cc2cc(F)ccc2F)c2ccccc2C1(C)C

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.41
MAPT P10636 3/20 0.41
MEN1 O00255 2/20 0.41
LMNA P02545 2/20 0.41
RECQL P46063 2/20 0.41
KMT2A Q03164 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
PLIN1 O60240 1/20 0.41
THRB P10828 1/20 0.41
PKM P14618 1/20 0.41
TSHR P16473 1/20 0.41
PLIN5 Q00G26 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ABHD5 Q8WTS1 1/20 0.41
NPSR1 Q6W5P4 2/20 0.33
ALPG P10696 1/20 0.33
TP53 P04637 1/20 0.33
ALOX15 P16050 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13419419 0.94 GAA (0.41) GAAMAPTMEN1LMNARECQL
SCHEMBL13419411 0.90 MAPT (0.42) GAAMAPTMEN1LMNARECQL
SCHEMBL12846404 0.90 GAA (0.44) GAAMAPTMEN1LMNARECQL
SCHEMBL13491281 0.89 GAA (0.43) GAAMAPTMEN1LMNARECQL
SCHEMBL13491301 0.89 GAA (0.41) GAAMAPTMEN1LMNARECQL
SCHEMBL12846405 0.87 GAA (0.45) GAAMAPTMEN1LMNARECQL
SCHEMBL13491012 0.86 MAPT (0.41) GAAMAPTMEN1LMNARECQL
SCHEMBL8780139 0.86 GAA (0.43) GAAMAPTMEN1LMNARECQL
SCHEMBL13491294 0.84 MAPT (0.43) GAAMAPTMEN1LMNARECQL
SCHEMBL12846409 0.84 GAA (0.40) GAAMAPTMEN1LMNARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2102307-B1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR FRESHPOINT HOLDINGS SA (CH) 2012-05-23 EP disclosed
US-20100034961-A1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR FRESHPOINT HOLDINGS SA (CH) 2010-02-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100034961-A1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR TTI1, NQO2, CCNI GAA 4192/4885MAPT 3732/4885MEN1 828/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.