SCHEMBL8778840

SCHEMBL8778840

N#Cc1cc(Br)c(Cl)nc1Cl

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KHK P50053 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.46
ALDH1A1 P00352 2/20 0.44
NPSR1 Q6W5P4 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
TDP1 Q9NUW8 1/20 0.38
KDM4E B2RXH2 1/20 0.36
GAA P10253 1/20 0.36
CHUK O15111 1/20 0.36
PKM P14618 1/20 0.36
POLB P06746 1/20 0.35
CSNK1A1 P48729 1/20 0.34
CLK4 Q9HAZ1 1/20 0.34
SLC1A5 Q15758 1/20 0.33
CYP11B2 P19099 1/20 0.33
GPR35 Q9HC97 1/20 0.33
PGK1 P00558 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL566209 0.84 KHK (0.57) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL30377261 0.82 KHK (0.62) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL29904594 0.82 NPSR1 (0.54) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL25216528 0.82 KHK (0.62) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL16828824 0.82 NPSR1 (0.54) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL29664344 0.79 KHK (0.42) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL20302559 0.78 ALDH1A1 (0.58) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL17649358 0.77 ALDH1A1 (0.45) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL16853715 0.77 GLA (0.44) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2
SCHEMBL20867776 0.77 KHK (0.45) KHKSMN1; SMN2ALDH1A1NPSR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3689875-B1 USE OF TRIAZOLOPYRIMIDINE, TRIAZOLOPYRIDINE COMPOUNDS AND COMPOSITION THEREOF FOR TREATING PRC2-MEDIATED DISEASES SHANGHAI INST MATERIA MEDICA CAS (CN) 2021-10-13 EP disclosed
EP-3689875-A1 USE OF TRIAZOLOPYRIMIDINE, TRIAZOLOPYRIDINE COMPOUNDS AND COMPOSITION THEREOF FOR TREATING PRC2-MEDIATED DISEASES Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2020-08-05 EP disclosed
WO-2019062435-A1 USE OF TRIAZOLOPYRIMIDINE, TRIAZOLOPYRIDINE COMPOUNDS AND COMPOSITION THEREOF FOR TREATING PRC2-MEDIATED DISEASES 中国科学院上海药物研究所 2019-04-04 WO disclosed
EP-0700903-B1 PROCESS FOR PRODUCING CYANOPYRIDINE IHARA CHEMICAL IND CO (JP) 1997-11-12 EP disclosed
US-5675012-A REACTING AMMONIUM HALIDE WITH TRICHLOROMETHYLPYRIDINE IN PRESENCE OF A COPPER AND ZINC COMPOUND IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1997-10-07 US disclosed
EP-0700903-A1 PROCESS FOR PRODUCING CYANOPYRIDINE IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-03-13 EP disclosed