Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | C1S | P09871 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL27755598 | 1.00 | ALDH1A1 (0.56) | ALDH1A1NPSR1F2F10F12 | |
| Benzene SCHEMBL27899224 | 0.97 | ALDH1A1 (0.58) | ALDH1A1NPSR1F2F10F12 | |
| SCHEMBL36862 | 0.97 | ALDH1A1 (0.58) | ALDH1A1NPSR1F2F10F12 | |
| SCHEMBL7529429 | 0.97 | ALDH1A1 (0.58) | ALDH1A1NPSR1F2F10F12 | |
| SCHEMBL1797820 | 0.97 | ALDH1A1 (0.58) | ALDH1A1NPSR1F2F10F12 | |
| Hydrochloric Acid SCHEMBL5813799 | 0.95 | ALDH1A1 (0.56) | ALDH1A1NPSR1F2F10F12 | |
| Bromide SCHEMBL668726 | 0.95 | ALDH1A1 (0.56) | ALDH1A1NPSR1F2F10F12 | |
| Hydrogen Sulfide SCHEMBL3400123 | 0.95 | ALDH1A1 (0.56) | ALDH1A1NPSR1F2F10F12 | |
| Fluoride SCHEMBL28947959 | 0.95 | ALDH1A1 (0.56) | ALDH1A1NPSR1F2F10F12 | |
| Water SCHEMBL27856253 | 0.95 | ALDH1A1 (0.56) | ALDH1A1NPSR1F2F10F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871824-B1 | COMPOUNDING SILICA-REINFORCED RUBBER WITH LOW VOLATILE ORGANIC COMPOUND (VOC) EMISSION | BRIDGESTONE CORP (JP) | 2017-03-01 | — | — | EP | claimed |
| EP-0545883-B1 | Innertube for tires | SEMPERIT AG (AT) | 1997-09-10 | — | — | EP | claimed |
| EP-0545883-A1 | Innertube for tires | Semperit Reifen Aktiengesellschaft (AT) | 1993-06-09 | — | — | EP | claimed |
| EP-3107712-B1 | SELF SEALING ARTICLES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2023-09-20 | — | — | EP | disclosed |
| US-11731394-B2 | Air and water barrier articles | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2023-08-22 | — | — | US | disclosed |
| EP-3174946-B1 | SELF SEALING PERMEABLE AIR BARRIER COMPOSITIONS | 3M INNOVATIVE PROPERTIES CO (US) | 2018-11-28 | — | — | EP | disclosed |
| CN-108250504-A | The tread rubber composition of commercial car tire | 三角轮胎股份有限公司 | 2018-07-06 | — | — | CN | disclosed |
| US-20180001595-A1 | AIR AND WATER BARRIER ARTICLES | 3M INNOVATIVE PROPERTIES COMPANY | 2018-01-04 | — | — | US | disclosed |
| EP-3237699-A1 | AIR AND WATER BARRIER ARTICLES | 3M Innovative Properties Company (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-3174946-A1 | SELF SEALING PERMEABLE AIR BARRIER COMPOSITIONS | 3M Innovative Properties Company (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-3107712-A2 | SELF SEALING ARTICLES | 3M Innovative Properties Company (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2016106273-A1 | AIR AND WATER BARRIER ARTICLES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016019248-A1 | SELF SEALING PERMEABLE AIR BARRIER COMPOSITIONS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2016-02-04 | — | — | WO | disclosed |
| US-20150368508-A1 | COATING COMPOSITIONS AND ARTICLES MADE THEREFROM | 3M INNOVATIVE PROPERTIES COMPANY | 2015-12-24 | — | — | US | disclosed |
| EP-2951234-A2 | COATING COMPOSITIONS AND ARTICLES MADE THEREFROM | 3M Innovative Properties Company (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014121007-A2 | COATING COMPOSITIONS AND ARTICLES MADE THEREFROM | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-08-07 | — | — | WO | disclosed |
| CN-1392890-A | Curable composition and use thereof | MITSUI CHEMICALS INC (JP) | 2003-01-22 | — | — | CN | disclosed |