Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | EEF2K | O00418 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779686 | 1.00 | CYP1A2 (0.68) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8779597 | 0.81 | CYP1A2 (0.45) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8779592 | 0.81 | CYP1A2 (0.45) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8822308 | 0.77 | PTGS2 (0.61) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8822313 | 0.77 | PTGS2 (0.61) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL28125511 | 0.77 | CYP1A2 (0.69) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8779637 | 0.77 | CYP1A2 (0.60) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL8779628 | 0.77 | CYP1A2 (0.60) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL9842786 | 0.76 | CNR2 (0.46) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 | |
| SCHEMBL9630123 | 0.76 | CNR2 (0.46) | CYP1A2CYP2C9PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204964-B1 | 2-PYRROLIDONE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | Eisai Co., Ltd. (JP) | 1991-08-28 | — | — | EP | claimed |
| EP-0204964-A1 | 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1986-12-17 | — | — | EP | claimed |
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| EP-0532767-B1 | 3-Phenoxybenzyl(idene)pyrrolidine derivatives, their preparation and their use as muscarinic cholinergic agents | KANEGAFUCHI CHEMICAL IND (JP) | 1997-03-05 | — | — | EP | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |
| CN-1014058-B | Process for preparing 2-pyrrolidone derivatives | EISAI CO LTD (JP) | 1991-09-25 | — | — | CN | disclosed |
| EP-0204964-B1 | 2-PYRROLIDONE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | Eisai Co., Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |
| EP-0391644-A2 | Aryl-substituted rhodanine derivatives | ELI LILLY AND COMPANY (US) | 1990-10-10 | — | — | EP | disclosed |
| US-4833160-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | EISAI CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| US-4833160-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | EISAI CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| US-4833160-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | EISAI CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| CN-86103227-A | The method for preparing the 2-Pyrrolidone derivative | — | 1987-01-21 | — | — | CN | disclosed |
| CN-86103227-A | The method for preparing the 2-Pyrrolidone derivative | — | 1987-01-21 | — | — | CN | disclosed |
| EP-0204964-A1 | 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |
| EP-0204964-A1 | 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |