Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603972 | 0.78 | HTT (0.39) | KMT2AMEN1SMN1; SMN2NPSR1RAB9A | |
| SCHEMBL2325685 | 0.71 | NPSR1 (0.44) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6156624 | 0.70 | TSHR (0.35) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9224354 | 0.68 | ALDH1A1 (0.42) | KMT2AMEN1CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL11079026 | 0.68 | ALDH1A1 (0.47) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5512049 | 0.67 | ALDH1A1 (0.47) | KMT2AMEN1SMN1; SMN2NPSR1RAB9A | |
| SCHEMBL27352619 | 0.67 | TSHR (0.43) | KMT2AMEN1SMN1; SMN2NPSR1RAB9A | |
| SCHEMBL5170181 | 0.67 | NPSR1 (0.40) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10784052 | 0.66 | ATM (0.48) | KMT2ASMN1; SMN2NPSR1RAB9AALDH1A1 | |
| SCHEMBL6330278 | 0.66 | HPGD (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |