SCHEMBL8780100

SCHEMBL8780100

O=C(O)CCCCC(=O)c1ccc2ccccc2c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 5/20 0.68
HDAC8 Q9BY41 3/20 0.68
SMN1; SMN2 Q16637 2/20 0.63
HPGD P15428 2/20 0.63
KDM4E B2RXH2 1/20 0.63
HDAC3 O15379 2/20 0.62
HDAC4 P56524 2/20 0.62
HDAC7 Q8WUI4 2/20 0.62
HDAC2 Q92769 2/20 0.62
HDAC10 Q969S8 2/20 0.62
HDAC11 Q96DB2 2/20 0.62
HDAC6 Q9UBN7 2/20 0.62
HDAC9 Q9UKV0 2/20 0.62
HDAC5 Q9UQL6 2/20 0.62
ALDH1A1 P00352 2/20 0.59
NPC1 O15118 1/20 0.59
RAB9A P51151 1/20 0.59
PTPN1 P18031 1/20 0.59
CYP1A2 P05177 2/20 0.58
CYP2C19 P33261 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3379592 0.98 HDAC1 (0.70) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL5286879 0.98 HDAC1 (0.70) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL5641458 0.97 HDAC1 (0.63) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL29435967 0.89 SMN1; SMN2 (0.72) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL3527398 0.89 SMN1; SMN2 (0.72) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL29435966 0.89 SMN1; SMN2 (0.72) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL13443094 0.86 PTPN1 (0.69) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL29171627 0.85 DPP4 (0.65) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL12065064 0.85 SMN1; SMN2 (0.67) HDAC1HDAC8SMN1; SMN2HPGDKDM4E
SCHEMBL7387271 0.85 HDAC1 (0.70) HDAC1HDAC8SMN1; SMN2HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662964-B1 HETEROCYCLIC AMINES HAVING CALMODULIN ANTAGONIST PROPERTIES BRITISH TECH GROUP (GB) 1997-06-11 EP disclosed
US-5543422-A HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS, FUNGICIDES BRITISH TECHNOLOGY GROUP LIMITED (GB) 1996-08-06 US disclosed
EP-0662964-A1 HETEROCYCLIC AMINES HAVING COLMODULIN ANTAGONIST PROPERTIES. BRITISH TECH GROUP (GB) 1995-07-19 EP disclosed
WO-1994007875-A1 HETEROCYCLIC AMINES HAVING COLMODULIN ANTAGONIST PROPERTIES BRITISH TECHNOLOGY GROUP LIMITED (GB) 1994-04-14 WO disclosed