Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381304 | 1.00 | HDAC1 (0.70) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL13443094 | 0.98 | PTPN1 (0.69) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL27529851 | 0.88 | PTPN1 (0.73) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL3379543 | 0.87 | HDAC1 (0.70) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL5286879 | 0.87 | HDAC1 (0.70) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL3379592 | 0.87 | HDAC1 (0.70) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL4953757 | 0.85 | HDAC1 (0.68) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL2821005 | 0.85 | HDAC1 (0.68) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL12952426 | 0.85 | HDAC1 (0.68) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL8780100 | 0.85 | HDAC1 (0.68) | HDAC1HDAC8PTPN1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |