Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785951 | 0.90 | GLRA1 (0.53) | GLRA1KMT2AMEN1TDP1THRB | |
| SCHEMBL15537162 | 0.85 | GLRA1 (0.48) | GLRA1KMT2AMEN1TDP1THRB | |
| SCHEMBL9516084 | 0.84 | GLRA1 (0.52) | GLRA1KMT2AMEN1TDP1THRB | |
| SCHEMBL8164051 | 0.82 | GLRA1 (0.57) | GLRA1HPGDALDH1A1MAOBLMNA | |
| SCHEMBL9516080 | 0.82 | GLRA1 (0.50) | GLRA1KMT2AMEN1TDP1THRB | |
| SCHEMBL31419968 | 0.81 | GLRA1 (0.62) | GLRA1KMT2AMEN1TDP1THRB | |
| SCHEMBL28005951 | 0.80 | GLRA1 (0.50) | GLRA1KMT2AMEN1TDP1THRB | |
| SCHEMBL4850986 | 0.79 | RXRA (0.41) | KMT2ATHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL16785954 | 0.79 | GLRA1 (0.63) | GLRA1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL6915900 | 0.78 | GLRA1 (0.59) | GLRA1TDP1SMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668126-A | ORAL ADMINISTRATION OF HMG-COA REDUCTASE INHIBITOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-16 | — | — | US | disclosed |
| US-5646272-A | WITH IMPROVED ABSORPTION INTO THE BLOODSTREAM | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | disclosed |
| EP-0417725-B1 | Bile-acid derivatives, a process for their production and their use as medicines | HOECHST AG (DE) | 1997-04-23 | — | — | EP | disclosed |
| US-5462933-A | Oral administering | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0341681-B1 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| EP-0417725-A2 | Bile-acid derivatives, a process for their production and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |
| EP-0341681-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-15 | — | — | EP | disclosed |