SCHEMBL878165

SCHEMBL878165

C=C(C#N)SN

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7848073 0.72
SCHEMBL3411630 0.67
SCHEMBL459630 0.62
SCHEMBL9874604 0.61
Hydrochloric Acid SCHEMBL28941852 0.60
SCHEMBL136969 0.57
SCHEMBL28774597 0.57 TDP1 (0.50)
SCHEMBL1889832 0.57
SCHEMBL270019 0.57
SCHEMBL11569766 0.57

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3409762-A1 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS The Scripps Research Institute (US) 2018-12-05 EP disclosed
EP-2955222-B1 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS SCRIPPS RESEARCH INST (US) 2018-09-12 EP disclosed
US-20180171303-A1 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE SCRIPPS RESEARCH INSTITUTE 2018-06-21 US disclosed
US-9926533-B2 Combined chemical and genetic approaches for generation of induced pluripotent stem cells THE SCRIPPS RESEARCH INSTITUTE (US) 2018-03-27 US disclosed
US-20180002671-A1 CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE SCRIPPS RESEARCH INSTITUTE 2018-01-04 US disclosed
US-9771563-B2 Chemical approaches for generation of induced pluripotent stem cells THE SCRIPPS RESEARCH INSTITUTE (US) 2017-09-26 US disclosed
US-20170081640-A1 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE SCRIPPS RESEARCH INSTITUTE 2017-03-23 US disclosed
US-9540615-B2 Combined chemical and genetic approaches for generation of induced pluripotent stem cells THE SCRIPPS RESEARCH INSTITUTE (US) 2017-01-10 US disclosed
US-9534205-B2 Combined chemical and genetic approaches for generation of induced pluripotent stem cells THE SCRIPPS RESEARCH INSTITUTE (US) 2017-01-03 US disclosed
US-20160369244-A1 CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE SCRIPPS RESEARCH INSTITUTE 2016-12-22 US disclosed
US-20040087583-A1 Amino-thio-acrylonitriles as MEK inhibitors HOBBS FRANK WORDEN (US) 2004-05-06 US disclosed
US-20040087583-A1 Amino-thio-acrylonitriles as MEK inhibitors HOBBS FRANK WORDEN (US) 2004-05-06 US disclosed
US-6703420-B1 MITOGEN ACTIVATED PROTEIN KINASE (MAPK) INHIBITORS; ANTIINFLAMMATORY, ANTICARCINOGENIC, OR ANTIPROLIFERATIVE AGENTS; RADIOSENSITIZERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-03-09 US disclosed
US-6703420-B1 MITOGEN ACTIVATED PROTEIN KINASE (MAPK) INHIBITORS; ANTIINFLAMMATORY, ANTICARCINOGENIC, OR ANTIPROLIFERATIVE AGENTS; RADIOSENSITIZERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-03-09 US disclosed
US-6703420-B1 MITOGEN ACTIVATED PROTEIN KINASE (MAPK) INHIBITORS; ANTIINFLAMMATORY, ANTICARCINOGENIC, OR ANTIPROLIFERATIVE AGENTS; RADIOSENSITIZERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-03-09 US disclosed
EP-1163215-A1 AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-12-19 EP disclosed
EP-1163215-A1 AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-12-19 EP disclosed
US-6214851-B1 AND A METHOD FOR TREATING OR PREVENTING A DISORDER RELATED TO MEK;ANTIINFLAMATORY,ANTICANCER AGENTS DUPONT PHARMACEUTICALS COMPANY 2001-04-10 US disclosed
WO-2000056706-A1 AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-09-28 WO disclosed
WO-2000056706-A1 AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-09-28 WO disclosed