Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.64 |
| ▸ | CD38 | P28907 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.60 |
| ▸ | FBP1 | P09467 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17845958 | 0.83 | EGFR (0.66) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL6189936 | 0.83 | EGFR (0.64) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL30301816 | 0.83 | EGFR (0.66) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL8782158 | 0.83 | EGFR (0.64) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL27757157 | 0.83 | EGFR (0.64) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL6190465 | 0.82 | EGFR (0.67) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL27757000 | 0.82 | EGFR (0.67) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL6188954 | 0.81 | EGFR (0.64) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL29667010 | 0.80 | EGFR (0.61) | EGFRCD38RAF1BRAFERBB2 | |
| SCHEMBL17858789 | 0.80 | EGFR (0.61) | EGFRCD38RAF1BRAFERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794953-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016960-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |