Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.74 |
| ▸ | MET | P08581 | 11/20 | 0.74 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CD38 | P28907 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782234 | 0.82 | EGFR (0.62) | KDRMETEGFRHTTHIF1A | |
| SCHEMBL6187944 | 0.81 | BRAF (0.73) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL4355660 | 0.79 | EGFR (0.55) | KDRMETEGFRHTTHIF1A | |
| SCHEMBL3391554 | 0.78 | EGFR (1.00) | KDREGFRHTTHIF1AERBB2 | |
| SCHEMBL8871863 | 0.78 | EGFR (0.82) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL13620922 | 0.77 | EGFR (0.67) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL159209 | 0.75 | EGFR (1.00) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL29350058 | 0.75 | EGFR (1.00) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL4349199 | 0.75 | MAPK1 (1.00) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL6884208 | 0.74 | KDR (0.49) | KDRMETEGFRHTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794953-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016960-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |