Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9934087 | 0.77 | HDAC1 (0.38) | — | |
| SCHEMBL17144176 | 0.76 | ADRA1A (0.35) | ADRA1AHTR2B | |
| SCHEMBL4790662 | 0.73 | HDAC1 (0.37) | — | |
| SCHEMBL25494193 | 0.72 | HTR2A (0.38) | ADRA1AHTR2AHTR2CHTR2B | |
| SCHEMBL17670504 | 0.71 | MKNK1 (0.35) | — | |
| SCHEMBL17549914 | 0.71 | MKNK1 (0.35) | — | |
| SCHEMBL15267544 | 0.71 | HTR2A (0.35) | HTR2AHTR2CHTR2B | |
| SCHEMBL11850205 | 0.70 | ADRA1A (0.37) | ADRA1AHTR2AHTR2CHTR2B | |
| SCHEMBL8784135 | 0.70 | UGT2B17 (0.42) | HTR2AHTR2CHTR2B | |
| SCHEMBL11522206 | 0.70 | HTR2A (0.35) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395244-B1 | Pyridine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| US-5194439-A | 5-HT Agonists or Antagonists, Nervous System Disorders, Hypotensive Agents | JOHN WYETH & BROTHER LIMITED (GB) | 1993-03-16 | — | — | US | disclosed |
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |