Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | EPOR | P19235 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783301 | 1.00 | ALOX5 (0.47) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL8782799 | 0.73 | ALOX5 (0.50) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL8782877 | 0.73 | ALOX5 (0.50) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL8783562 | 0.73 | ALOX5 (0.42) | ALOX5PTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL8782845 | 0.72 | ALOX5 (0.53) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL17050385 | 0.72 | ALOX5 (0.53) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL8782833 | 0.72 | ALOX5 (0.53) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9514647 | 0.71 | ALOX5 (0.80) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9517954 | 0.71 | ALOX5 (0.80) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9515717 | 0.71 | ALOX5 (0.80) | ALOX5PTGS1PTGS2ALOX5APEPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | claimed |
| US-5214204-A | Inhibitors of biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | claimed |