Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784047 | 0.86 | MEN1 (0.54) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL8783960 | 0.86 | MEN1 (0.54) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL8785078 | 0.86 | MEN1 (0.63) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL9098209 | 0.84 | MEN1 (0.52) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL8784073 | 0.83 | KMT2A (0.56) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL8153325 | 0.83 | MEN1 (0.58) | MEN1KMT2APOLBABL1MAPT | |
| SCHEMBL8785479 | 0.82 | POLB (0.54) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL8785627 | 0.82 | MEN1 (0.50) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL8784013 | 0.82 | L3MBTL1 (0.60) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL9098202 | 0.82 | MEN1 (0.50) | MEN1KMT2APOLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481676-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5559125-A | NMDA AND AMPA RECEPTOR ANTAGONISTS, SCHIZOPHRENIA | MERCK, SHARP & DOHME LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| US-5348962-A | Nervous system disorders; schizophrenia | MERCK SHARPE & DOHME LTD. | 1994-09-20 | — | — | US | disclosed |
| EP-0481676-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-04-22 | — | — | EP | disclosed |