Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.64 |
| ▸ | EDNRB | P24530 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784547 | 0.91 | EDNRA (0.64) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL7939780 | 0.81 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL8784519 | 0.81 | EDNRA (0.76) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL3500159 | 0.80 | EDNRA (0.76) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL15010097 | 0.80 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL8784088 | 0.80 | EDNRA (0.74) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL7947202 | 0.79 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL15010361 | 0.79 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL7946125 | 0.78 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL13284801 | 0.78 | EDNRA (0.67) | EDNRAEDNRBMEN1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | claimed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |