SCHEMBL3500159

SCHEMBL3500159

Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 10/20 0.76
EDNRB P24530 8/20 0.72
MEN1 O00255 1/20 0.71
CYP2C9 P11712 1/20 0.71
TSHR P16473 1/20 0.71
CYP2C19 P33261 1/20 0.71
ADRA1A P35348 1/20 0.71
KMT2A Q03164 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8977979 0.87 EDNRA (0.77) EDNRAEDNRB
SCHEMBL8784519 0.84 EDNRA (0.76) EDNRAEDNRBMEN1CYP2C9TSHR
SCHEMBL8784088 0.83 EDNRA (0.74) EDNRAEDNRBMEN1CYP2C9TSHR
Sulfisoxazole SCHEMBL788644 0.83 EDNRA (1.00) EDNRAEDNRBMEN1CYP2C9TSHR
Sulfisoxazole SCHEMBL23467 0.83 EDNRA (1.00) EDNRAEDNRBMEN1CYP2C9TSHR
SCHEMBL7716850 0.83 EDNRA (1.00) EDNRAEDNRBMEN1CYP2C9TSHR
SCHEMBL6150845 0.83 EDNRA (1.00) EDNRAEDNRB
Sulfisoxazole SCHEMBL2200933 0.82 EDNRA (0.97) EDNRAEDNRBMEN1CYP2C9TSHR
Sulfisoxazole SCHEMBL5917298 0.82 EDNRA (0.97) EDNRAEDNRBMEN1CYP2C9TSHR
SCHEMBL8784374 0.80 EDNRA (0.64) EDNRAEDNRBMEN1CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4315931-A MICROBIOCIDES, INFECTIOUS DISEASES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US claimed
US-3996356-A ANTIBACTERIAL HOFFMANN-LA ROCHE INC. (US) 1976-12-07 US claimed
US-20160369237-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY ADVANCED CELL TECH INC (US) 2016-12-22 US disclosed
US-20100184033-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY Lineage Cell Therapeutics, Inc. 2010-07-22 US disclosed
US-20080226601-A1 Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods UNIVERSITY OF ROCHESTER (US) 2008-09-18 US disclosed
EP-1903873-A2 HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS THE UNIVERSITY OF ROCHESTER (US) 2008-04-02 EP disclosed
US-20080070303-A1 Using myocardial and/or muscle progenitor cells as modeling tool in tissue engineering; regenerative medicine and organ replacement ADVANCED CELL TECHNOLOGY 2008-03-20 US disclosed
WO-2006135602-A2 HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS UNIVERSITY OF ROCHESTER (US) 2006-12-21 WO disclosed
EP-1069114-A2 Sulfonamides and derivatives thereof that modulate the activity of endothelin TEXAS BIOTECHNOLOGY CORPORATION (US) 2001-01-17 EP disclosed
EP-0870764-A1 Sulfonamides and derivatives thereof that modulate the activity of endothelin TEXAS BIOTECHNOLOGY CORPORATION (US) 1998-10-14 EP disclosed
US-5571821-A CARDIOVASCULAR DISORDERS TO MODULATE ENDOTHELIN, HYPOTENSIVE AGENTS AND VASOCONSTRICTION TEXAS BIOTECHNOLOGY CORPORATION (US) 1996-11-05 US disclosed
US-4333936-A Novel amidino-benzylpyrimidines, processes for their manufacture and antibacterial and antiprotozoal use thereof BASF AKTIENGESELLSCHAFT (DE) 1982-06-08 US disclosed
US-4315931-A MICROBIOCIDES, INFECTIOUS DISEASES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US disclosed
EP-0000335-B1 ESTERS OF N-PYRIMIDINYL-CARBOXIMIDIC ACID, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM. BASF Aktiengesellschaft (DE) 1981-10-07 EP disclosed
EP-0000336-B1 N-BENZYLPYRIMIDINYL-AMIDINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM BASF Aktiengesellschaft (DE) 1981-04-15 EP disclosed
EP-0000335-A1 Esters of N-pyrimidinyl-carboximidic acid, process for their preparation and medicines containing them. BASF Aktiengesellschaft (DE) 1979-01-24 EP disclosed
US-4125610-A PHOSPHANILIC ACID AND TRIMETHOPRIM BRISTOL-MYERS COMPANY (US) 1978-11-14 US disclosed
US-3996356-A ANTIBACTERIAL HOFFMANN-LA ROCHE INC. (US) 1976-12-07 US disclosed
US-3996356-A ANTIBACTERIAL HOFFMANN-LA ROCHE INC. (US) 1976-12-07 US disclosed
US-3996356-A ANTIBACTERIAL HOFFMANN-LA ROCHE INC. (US) 1976-12-07 US disclosed