Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.81 |
| ▸ | DRD2 | P14416 | 5/20 | 0.72 |
| ▸ | HTR1A | P08908 | 8/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583198 | 0.93 | KCNH2 (0.78) | KCNH2DRD2HTR1AHTR7KDM4E | |
| SCHEMBL4525293 | 0.90 | KCNH2 (1.00) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL8828388 | 0.86 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7KDM4E | |
| SCHEMBL9027593 | 0.86 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7KDM4E | |
| SCHEMBL27906495 | 0.86 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7KDM4E | |
| SCHEMBL10835591 | 0.86 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7KDM4E | |
| SCHEMBL11404382 | 0.86 | KCNH2 (0.81) | KCNH2DRD2HTR1AHTR7KDM4E | |
| SCHEMBL9449554 | 0.85 | KCNH2 (0.70) | KCNH2DRD2HTR1AKDM4EALDH1A1 | |
| SCHEMBL3198597 | 0.84 | KCNH2 (0.84) | KCNH2DRD2HTR1AHTR7HTR2A | |
| SCHEMBL30873546 | 0.84 | KCNH2 (0.84) | KCNH2DRD2HTR1AHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478446-B1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-11-19 | — | — | EP | disclosed |
| EP-0478446-A1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-01 | — | — | EP | disclosed |