Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 17/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8786926 | 0.89 | SIGMAR1 (0.78) | SIGMAR1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL8786565 | 0.88 | SIGMAR1 (0.80) | SIGMAR1 | |
| SCHEMBL28647889 | 0.88 | SIGMAR1 (0.78) | SIGMAR1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL8786543 | 0.87 | SIGMAR1 (0.79) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8787136 | 0.84 | SIGMAR1 (0.98) | SIGMAR1 | |
| SCHEMBL8787025 | 0.84 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL8786706 | 0.84 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL8788283 | 0.84 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL8786635 | 0.84 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL8787028 | 0.84 | SIGMAR1 (1.00) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533804-B1 | SIGMA BINDING SITE AGENTS | GUILFORD PHARM INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5359098-A | For psychological disorders; antipsychotic drugs | GUILFORD PHARMACEUTICALS INC. (US) | 1994-10-25 | — | — | US | disclosed |
| US-5278174-A | Receptivity | SCIOS NOVA, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0533804-A4 | SIGMA BINDING SITE AGENTS | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0533804-A1 | SIGMA BINDING SITE AGENTS | GUILFORD PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991018597-A1 | SIGMA BINDING SITE AGENTS | ERICKSON RONALD H (US) | 1991-12-12 | — | — | WO | disclosed |