Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.67 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.67 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591654 | 0.92 | DRD4 (0.84) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL9592718 | 0.92 | DRD4 (0.84) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL9592321 | 0.90 | DRD4 (0.80) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL694949 | 0.89 | SIGMAR1 (0.82) | DRD4KMT2ADRD2SIGMAR1TMEM97 | |
| SCHEMBL9593089 | 0.89 | DRD4 (0.79) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL9592422 | 0.89 | DRD4 (0.79) | DRD4KMT2ASIGMAR1TMEM97SLC6A12 | |
| SCHEMBL9592418 | 0.89 | DRD4 (0.79) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL9592555 | 0.89 | DRD4 (0.79) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL9591760 | 0.89 | KMT2A (0.83) | DRD4KMT2ADRD2DRD3SIGMAR1 | |
| SCHEMBL9593263 | 0.89 | DRD4 (0.79) | DRD4KMT2ADRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719264-B1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME (GB) | 1997-12-29 | — | — | EP | disclosed |
| US-5698573-A | Imidazolone and oxazolone derivatives as dopamine antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-12-16 | — | — | US | disclosed |