SCHEMBL8787162

SCHEMBL8787162

CC(O)C(=O)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.52
CES1 P23141 3/20 0.52
ALOX15 P16050 1/20 0.50
TSHR P16473 1/20 0.50
ALDH1A1 P00352 3/20 0.48
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
TRPA1 O75762 2/20 0.47
MAPT P10636 2/20 0.46
GSK3B P49841 2/20 0.45
SRD5A2 P31213 1/20 0.45
MAPK1 P28482 1/20 0.45
HTT P42858 1/20 0.44
HPGD P15428 1/20 0.44
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CA12 O43570 1/20 0.43
CA9 Q16790 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21456599 0.88 KDM4E (0.43) CES2CES1TSHRALDH1A1CA1
SCHEMBL2625462 0.84 CES2 (0.54) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL9520784 0.82 CES2 (0.52) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL10709870 0.82 CYP2C9 (0.52) CES2CES1ALDH1A1MAPK1HTT
SCHEMBL1144070 0.82 CES2 (0.52) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL1673551 0.81 CES2 (0.56) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL8022083 0.80 CES2 (0.50) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL16690275 0.80 CES2 (0.50) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL634548 0.80 CES2 (0.50) CES2CES1ALOX15TSHRALDH1A1
SCHEMBL187689 0.80 CES2 (0.50) CES2CES1ALOX15TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119263946-A Preparation method of alpha-acyloxyketone compound 华南师范大学 2025-01-07 CN disclosed
CN-117603436-A Polymer, modified polyurethane elastomer and preparation method thereof 北京大学 2024-02-27 CN disclosed
CN-108083999-B Green preparation method of alpha-hydroxyketone 西北师范大学 2020-08-11 CN disclosed
EP-2543658-B1 METHOD FOR PRODUCING A-ACYLOXYCARBONYL COMPOUND AND NOVEL A-ACYLOXYCARBONYL COMPOUND UNIV NAGOYA NAT UNIV CORP (JP) 2015-05-06 EP disclosed
EP-2543658-A1 METHOD FOR PRODUCING A-ACYLOXYCARBONYL COMPOUND AND NOVEL A-ACYLOXYCARBONYL COMPOUND National University Corporation Nagoya University (JP) 2013-01-09 EP disclosed
EP-1048737-B1 Stereoselective synthesis of 2-hydroxycétones FORSCHUNGSZENTRUM JUELICH GMBH (DE) 2007-06-06 EP disclosed
EP-0719264-B1 IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS MERCK SHARP & DOHME (GB) 1997-12-29 EP disclosed
US-5698573-A Imidazolone and oxazolone derivatives as dopamine antagonists MERCK, SHARP & DOHME, LTD. (GB) 1997-12-16 US disclosed
EP-0719264-A1 IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS MERCK SHARP & DOHME LTD. (GB) 1996-07-03 EP disclosed
WO-1995007904-A1 IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 1995-03-23 WO disclosed
US-4499104-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTICONVULSANT AGENTS FARMATIS S.R.L. (IT) 1985-02-12 US disclosed
US-4499104-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTICONVULSANT AGENTS FARMATIS S.R.L. (IT) 1985-02-12 US disclosed
US-4004033-A GRAMNEGATIVE BACTERIA, FUNGICIDES CIBA-GEIGY CORPORATION (US) 1977-01-18 US disclosed