Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8787041 | 0.88 | KMT2A (0.43) | ALDH1A1KMT2APOLBSMN1; SMN2MAPK1 | |
| SCHEMBL2972573 | 0.85 | ALDH1A1 (0.51) | ALDH1A1HPGDTSHRKMT2AMAPK1 | |
| SCHEMBL394093 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL23326402 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KMT2ANPC1POLBRAB9A | |
| SCHEMBL8571445 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TSHRFFAR1KMT2ANPC1 | |
| SCHEMBL9385235 | 0.75 | ALDH1A1 (0.60) | ALDH1A1FFAR1KMT2ANPC1POLB | |
| SCHEMBL3727515 | 0.74 | FFAR1 (0.60) | ALDH1A1TSHRFFAR1KMT2ANPC1 | |
| SCHEMBL31252092 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19664220 | 0.74 | ALDH1A1 (0.62) | ALDH1A1KMT2ANPC1POLBRAB9A | |
| SCHEMBL3732372 | 0.73 | ALDH1A1 (0.59) | ALDH1A1FFAR1KMT2ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| EP-0681580-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES. | PFIZER HOSPITAL PROD (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017061-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |