Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12959974 | 0.76 | MAPT (0.50) | RAB9ANPC1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL858200 | 0.75 | S1PR1 (0.48) | RAB9ANPC1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL13138653 | 0.70 | S1PR1 (0.39) | RAB9ANPC1SMN1; SMN2ALDH1A1S1PR1 | |
| SCHEMBL14441202 | 0.64 | TDP1 (0.51) | RAB9ANPC1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL12346375 | 0.63 | MRGPRX4 (0.31) | — | |
| SCHEMBL6691870 | 0.61 | TSHR (0.54) | RAB9ANPC1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL13138769 | 0.61 | PARP1 (0.45) | ALDH1A1TSHRKDM4EHPGDHSD17B10 | |
| SCHEMBL858129 | 0.61 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL858331 | 0.60 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL9491202 | 0.59 | TSHR (0.94) | ALDH1A1TSHRKDM4ELMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |