Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.54 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634147 | 0.88 | ECE1 (0.55) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8788346 | 0.88 | ECE1 (0.55) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8788107 | 0.85 | ECE1 (0.56) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8791589 | 0.84 | ECE1 (0.57) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8788365 | 0.83 | ECE1 (0.53) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8789103 | 0.82 | ECE1 (0.55) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8788938 | 0.82 | ECE1 (0.57) | ECE1MUS81MAOAMAOBCDC25B | |
| Hydrochloric Acid SCHEMBL8788992 | 0.81 | ECE1 (0.56) | ECE1MUS81MAOAMAOBCDC25B | |
| Pixantrone SCHEMBL29372192 | 0.80 | ECE1 (0.72) | ECE1MUS81MAOAMAOBCDC25B | |
| SCHEMBL8788420 | 0.80 | BLM (0.61) | ECE1MUS81MAOAMAOBCDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503537-B1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | UNIV VERMONT (US) | 1997-05-14 | — | — | EP | claimed |
| EP-0575526-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1993-12-29 | — | — | EP | claimed |
| WO-1992015300-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1992-09-17 | — | — | WO | claimed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | claimed |
| EP-0503537-B1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | UNIV VERMONT (US) | 1997-05-14 | — | — | EP | disclosed |
| EP-0575526-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992015300-A1 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES | THE UNIVERSITY OF VERMONT (US) | 1992-09-17 | — | — | WO | disclosed |
| EP-0503537-A1 | 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones | THE UNIVERSITY OF VERMONT (US) | 1992-09-16 | — | — | EP | disclosed |