Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378752 | 0.88 | CYP3A4 (0.48) | MAPTLMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL2705489 | 0.83 | CYP3A4 (0.50) | MAPTLMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL8788538 | 0.82 | CYP3A4 (0.49) | MAPTCYP3A4ALDH1A1KMT2AMAPK1 | |
| SCHEMBL8787550 | 0.82 | MEN1 (0.52) | MAPTLMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL8787003 | 0.82 | MAPT (0.52) | MAPTLMNACYP3A4MEN1KMT2A | |
| SCHEMBL1571262 | 0.81 | AKR1C3 (0.54) | MAPTLMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL8787389 | 0.80 | PARP1 (0.49) | MAPTLMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL1632528 | 0.79 | ALDH1A1 (0.57) | MAPTLMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL17700760 | 0.79 | CYP3A4 (0.51) | LMNACYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL8786984 | 0.79 | ALDH1A1 (0.60) | MAPTCYP3A4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508682-B1 | Antibiotic carbapenem derivatives | ZENECA LTD (GB) | 1997-07-23 | — | — | EP | disclosed |
| US-5541178-A | THIENAMYCINS | ZENECA LIMITED (GB) | 1996-07-30 | — | — | US | disclosed |
| WO-1992017481-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |
| EP-0508682-A1 | Antibiotic carbapenem derivatives | ZENECA LIMITED (GB) | 1992-10-14 | — | — | EP | disclosed |