SCHEMBL878831

SCHEMBL878831

Ic1ccc2c(c1)c1ccccc1c1nccn21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 2/20 0.35
MAPK8 P45983 6/20 0.33
HTR3E A5X5Y0 2/20 0.33
HTR3B O95264 2/20 0.33
HTR3A P46098 2/20 0.33
HTR3D Q70Z44 2/20 0.33
HTR3C Q8WXA8 2/20 0.33
DNMT1 P26358 1/20 0.32
IKBKB O14920 1/20 0.31
PTAFR P25105 1/20 0.31
PARP1 P09874 1/20 0.31
DDB1 Q16531 1/20 0.31
CRBN Q96SW2 1/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIA1 P42261 1/20 0.31
GRIA2 P42262 1/20 0.31
GRIA3 P42263 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12828412 0.88 TACR1 (0.33) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL840406 0.81 MAPK8 (0.41) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL29636632 0.81 MAPK8 (0.41) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL841596 0.81 IKBKB (0.46) TACR1HTR3EHTR3BHTR3AHTR3D
SCHEMBL840434 0.81 MAPT (0.39) TACR1DDB1CRBNGRIN2DGRIN3B
SCHEMBL840323 0.81 TACR1 (0.35) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL21575495 0.81 MAPK8 (0.35) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL20881837 0.81 TACR1 (0.35) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL22349169 0.81 CCNE1 (0.37) TACR1MAPK8HTR3EHTR3BHTR3A
SCHEMBL20881858 0.81 KMT2A (0.43) TACR1MAPK8HTR3EHTR3BHTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8142909-B2 Blue phosphorescent imidazophenanthridine materials UNIVERSAL DISPLAY CORPORATION (US) 2012-03-27 US disclosed
US-7915415-B2 Metal complexes of cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1′,2′-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof UNIVERSAL DISPLAY CORPORATION (US) 2011-03-29 US disclosed
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS UNIVERSAL DISPLAY CORPORATION 2008-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080297033-A1 BLUE PHOSPHORESCENT IMIDAZOPHENANTHRIDINE MATERIALS IK, CRY1, MAP1LC3C TACR1 4123/4885MAPK8 3076/4885HTR3E 2249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.