Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8786227 | 0.91 | GAA (0.52) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8787448 | 0.87 | GAA (0.47) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8810151 | 0.85 | GAA (0.46) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8884073 | 0.83 | GAA (0.55) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL4407803 | 0.83 | GAA (0.55) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8786359 | 0.83 | SMPD1 (0.47) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8785758 | 0.83 | SMPD1 (0.47) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8808599 | 0.83 | SMPD1 (0.45) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8810764 | 0.83 | SMPD1 (0.45) | GAAMAPTSMN1; SMN2HPGDSMPD1 | |
| SCHEMBL8810909 | 0.83 | SMPD1 (0.45) | GAAMAPTSMN1; SMN2HPGDSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650961-B1 | Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments | HOECHST AG (DE) | 1997-03-05 | — | — | EP | disclosed |
| EP-0650960-B1 | Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments | HOECHST AG (DE) | 1997-03-05 | — | — | EP | disclosed |
| EP-0650961-A1 | Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-03 | — | — | EP | disclosed |
| EP-0650960-A1 | Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-03 | — | — | EP | disclosed |