Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790733 | 0.90 | ABCG2 (0.49) | ABCG2ABCB1CFTRPBRM1TP53 | |
| SCHEMBL8788654 | 0.88 | TP53 (0.48) | ABCG2CFTRMAOBPBRM1TP53 | |
| SCHEMBL8789542 | 0.86 | ABCG2 (0.54) | ABCG2ABCB1CFTRMAOBPBRM1 | |
| SCHEMBL8790125 | 0.86 | ABCG2 (0.65) | ABCG2ABCB1TP53MAPTMEN1 | |
| SCHEMBL8789989 | 0.85 | ABCG2 (0.63) | ABCG2ABCB1TP53MAPTMEN1 | |
| SCHEMBL8791484 | 0.84 | ABCG2 (0.62) | ABCG2ABCB1TP53MAPTMEN1 | |
| SCHEMBL8810838 | 0.83 | ALDH1A1 (0.41) | MAOBTP53MAPTALDH1A1MEN1 | |
| SCHEMBL8789166 | 0.82 | ABCG2 (0.65) | ABCG2ABCB1TP53MAPTMEN1 | |
| SCHEMBL8788454 | 0.82 | ABCG2 (0.64) | ABCG2ABCB1TP53MAPTMEN1 | |
| SCHEMBL8789962 | 0.80 | ABCG2 (0.65) | ABCG2ABCB1TP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |